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| LSU vs Southern CalOverall Record Against Southern Cal: 1-2-0 | ||||
| Date | Season | Result | Location | Notes | |
| Sep. 1 | 2024 | L 20-27 | Las Vegas | ||
| Sep. 29 | 1984 | W 23-3 | Los Angeles | ||
| Sep. 29 | 1979 | L 12-17 | Baton Rouge | ||
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