If this moronic idea were to ever escalate to a meaningful movement, all the US would have to do is create an embargo on all goods to the seceding states and watch them collapse before they could even begin to take flight.
Wouldn't exactly be a smart move by the FedGov. If Texas and Louisiana were to join up and secede, they would combine for a greater GDP than each of Canada, India, Russia, and Australia. Enforcing an embargo on them would not be an insignificant detriment to the rest of the US's economy. Sad that you (or anyone) would support such a thing to punish a region that wants nothing to do with the direction the country is moving.
Let me ask you this: if the White House asked Canada to join the US as, say, 10 different states, and they refused, would you support an embargo on them? Now take into account historical fallacy, what is the difference between that and Texas/LA seceding?