Hello TD.
It has always bugged me how the NCAA tourney has brackets based on region yet has teams from out of region playing in each yearly. It is not right.
I propose that each team gets put into a bracket based on what there state falls into BEFORE seeding takes place.
The only time any teams should be seeded vs others before finding a bracket is to help remove excess teams from 1 bracket and moving them to another there state falls in (lower seeds being the ones that move in such a case).
Then after each region has 17 teams (damn you play in game!!!) appropriate to there region seed everyone and begin.

Now I know what everyone is asking. Well what states feed which regions? Well it is simple. Note Some states are in multiple regions. Those as such are outlined as to which are there secondary regions to go to to help fill them out if necessary.

East = Any state with any part no matter how small in the Eastern Time Zone + DC.
(Indiana, Michigan, Ohio, Florida, Georgia, NC, SC, Tennessee, and Virginia have as Secondary region)

South = Virginia, NC, SC, Tennessee, Georgia, Florida, Alabama, Mississippi, Arkansas, Louisiana, Texas, Oklahoma, New Mexico, Arizona, Hawaii.
(Arizona, Hawaii, and New Mexico have as Secondary region)

Midwest = ND, SD, Nebraska, Kansas, Oklahoma, Texas, Minnesota, Iowa, Missouri, Wisconsin, Illinois, Indiana, Ohio, Michigan.
(Oklahoma + Texas have as Secondary region)

West = Any state with any part no matter how small in the West or Mountain Time Zones + Hawaii.
(ND, SD, Nebraska, Kansas, have as Secondary region) (Texas has a Tertiary region)

Also all the games in each region should be played in the same city (for that year not yearly). With only the final 4 and championship being played at a different venue. Either the games should be played in the largest city of the top seed per region (Philly, Miami, Wichita, Phoenix based on bracket below). Or pick a place in the regions a year in advance and rotate it between several other venues. Either is ok.

Now using this year's tournament teams here is how the brackets should look if teams were selected to there regions more logically and appropriately.

East
1. Villanova
2. Syracuse
3. Louisville
4. UMass
5. Connecticut
6. Kentucky
7. Pittsburgh
8. George Washington
9. Saint Joe's
10. Providence
11. Harvard
12. Delaware
13. Manhattan
14. American
15. Eastern Kentucky
16. Albany
16. Mount Saint Mary's

South
1. Florida
2. Virginia
3. Duke
4. VCU
5. North Carolina
6. Baylor
7. Texas
8. Memphis
9. Tennessee
10. NC State
11. Stephen F. Austin
12. Mercer
13. Louisiana Lafayette
14. NC Central
15. Wofford
16. Coastal Carolina
16. Texas Southern

Midwest
1. Wichita State
2. Wisconsin
3. Michigan
4. Kansas
5. Iowa State
6. Michigan State
7. Saint Louis
8. Oklahoma
9. Cincinnati
10. Ohio State
11. Oklahoma State
12. Iowa
13. Dayton
14. Xavier
15. Tulsa
16. Milwaukee
16. Western Michigan

West
1. Arizona
2. Creighton
3. UCLA
4. San Diego State
5. New Mexico
6. Oregon
7. Gonzaga
8. Colorado
9. Kansas State
10. Arizona State
11. Stanford
12. BYU
13. Nebraska
14. North Dakota State
15. New Mexico State
16. Weber State
16. Cal Poly

This is how the tournament should be.