All computer programs "Not Responding"

Anytime I open a program, no matter what program it is, it hangs up and eventually gives the “not responding” message. The computer is basically unusable like this. I can’t even run an anti-virus scan in normal mode due to this. I did run a Microsoft Security Essentials scan and a Malwarebytes scan in safe mode, and no threats were detected. Also tried a clean boot, still nothing responds. So I can't do anything in normal mood, but safe mode works fine. I have googled for suggestions, but was wondering if anyone here had any ideas.

I already posted this on the OT, but was told I may get better responses here. Thanks in advance to anyone who can help.