Unless D&Q will be a wash stop since I can get everything at Spec's?
You'll probably find anything you want at the Smith St. Spec's.
What shall I look for and go after that I can't get in Louisiana?
Dogfish Head, Avery, Great Divide, Deschutes, Ska, Oskar Blues, Sixpoint, Victory, plus all the Texas brands like Jester King, Real Ale, Karbach, etc... this could be a long list.
We also talked about Saint Arnold Brewery tour on Saturday. Should we skip that and do Karbach?
Absolutely you should skip Saint Arnold and do Karbach. Karbach also has a Friday happy hour tour if you are there in time, then you can do that Friday and hit up Saint Arnold or Buffalo Bayou Brewing on Saturday. Karbach >> Saint Arnold though if you have to pick.