re: Gerard Depardieu, 65, admits to drinking 14 bottles of wine a day

Andre the Giant holds the world record for the largest number of beers consumed in a single sitting. These were standard 12-ounce bottles of beer, nothing fancy, but during a six-hour period Andre drank 119 of them.
LINK Some other great stories in there.

My ex's dad could drink all day and be stone sober. He would drink screwdrivers for breakfast then go get a few bloody marys, then go to another bar then go to lunch then go to another bar, then go to a drive through and get a drink on his way home. He would fix dinner for his wife and go back to the bar for a few more then get one for the road on his way home.

He would mix liquor wine and beer all day, and never had a hangover.

Probably drinking more Vodka than Wine these days, is he still living in Russia?

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drinking 14 bottles of wine a day

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I don't see how that's possible unless he's on some other type of drug every day like amphetamines or something.

Explains his teeth

he doesn't get drunk, yet he pissed in the first class aisle of an Air France plane? lol


He owns his own vineyard, I guess it's easy to build up so high a tolerance with non stop wine.

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He would mix liquor wine and beer all day, and never had a hangover.

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Because he never stopped drinking.

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Yes, that is apparently key, which is why drinking when hungover often quickly relieves hangover symptoms (hair of the dog).

I might get the science a little mixed up, but when you drink, your body considers the alcohol a toxin. The body initially processes the alcohol (ethanol), into acetaldehyde, which is further broken down into other byproducts.

The hangover results from acetaldehyde or perhaps one of the other byproducts as your body continues to process them until they are fully broken down into water, CO2, etc. I don't think it is the poison that makes you feel so bad so much as it is the way the body reacts to rid itself of the poison (which consumes a lot of water, vitamins, etc.).

Regardless, both ethanol and acetaldehyde are poisons, but as I understand it, the body always reverts to dealing with ethanol first. So, if you have a bad hangover and your body is trying to clear out acetaldehyde or other secondary poisons, when you start drinking again your body essentially says, "Whoa! Stop messing with those secondary poisons. There's more ethanol to deal with now!" The body reverts to converting the alcohol into acetaldehyde, and temporarily ignores the acetaldehyde; and as soon as it does, the severity of the hangover is less intense. And sometimes you can drink your way back to euphoria.

Of course, the build up of byproducts will likely be all the worse the longer you put it off, unless you start drinking a lot of water, taking vitamins, and try to coast down a little more easily at some point.

Mr. Creosote, it's waaafer thin.

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- 65-year-old says that he 'never gets drunk' despite voluminous intake

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Oh yeah? We've heard that before:
LINK

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Snoop Dogg: I Smoke 81 Blunts A Day

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Not believing that. That's around a blunt every ten minutes every hour he's awake.