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re: The GLP-1 Protocol

Posted on 11/15/23 at 1:32 pm to
Posted by Uncle JackD
Member since Nov 2007
58659 posts
Posted on 11/15/23 at 1:32 pm to
quote:

unless you're 600 pounds.
Oh, FFS.

quote:

50-80 pounds


quote:

in 3-6 months



Like it or not, these meds are the future. Sema and tirz are making ripples at crazy pace and retatrutide is coming hot down the pipeline with amazing results.
This post was edited on 11/15/23 at 1:33 pm
Posted by TigerFanatic99
South Bend, Indiana
Member since Jan 2007
27678 posts
Posted on 2/25/24 at 5:20 pm to
Hey LSU777 -

Is this protocol intended for men, women, or both? I see products like Sustain Alpha, which generally is not for women. What would need to be adjusted out if this to apply it to a woman.

For transparency, I'm talking about an actual female with lady parts both at birth and today.
Posted by TheOcean
#honeyfriedchicken
Member since Aug 2004
42535 posts
Posted on 2/25/24 at 8:13 pm to
Awesome post

What size needle do you recommend for TRT and Tirz? Looking for something I can easily inject into my arm
Posted by lsu777
Lake Charles
Member since Jan 2004
31419 posts
Posted on 2/26/24 at 7:45 am to
5/8" or 1" 27g or 29g" to inject, 20g" to draw

for both
Posted by lsu1987
Baton Rouge
Member since Dec 2005
441 posts
Posted on 2/26/24 at 10:32 am to
Another question for 777 and others… What is the significance (during this protocol) of taking a magnesium supplement daily? I take a multivitamin which contains 140 mg of magnesium, the label claims it’s 33% of recommended daily intake. Is that enough, assuming I get magnesium through other sources of daily food intake?
Posted by Uncle JackD
Member since Nov 2007
58659 posts
Posted on 2/26/24 at 10:37 am to
I take mag oxide supplements daily for bowel regularity. I know some take mag glycinate to help with sleep.
Posted by TheOcean
#honeyfriedchicken
Member since Aug 2004
42535 posts
Posted on 3/12/24 at 12:59 pm to
Week two down on tirz. Down 4 lbs. About 10 lbs from my goal weight. Completely changed how I eat and feel way better

I am way more constipated than normal and have had some slight stomach pain. Taking Metamucil daily now
This post was edited on 3/12/24 at 1:00 pm
Posted by Uncle JackD
Member since Nov 2007
58659 posts
Posted on 3/12/24 at 3:28 pm to
What dose are you on? 2.5?

Drink a shite load of water, I do at least a gallon. And try some mag supplements to help with regularity. I haven’t experienced constipation but it is definitely a possible side effect due to the slowed motility.
Posted by BawtHouse
Member since Dec 2021
204 posts
Posted on 3/13/24 at 6:25 am to
Obesity is a disease.

One’s appearance has no bearing on the presence of a disease. If your body doesn’t naturally produce enough GLP-1, it doesn’t. Your assumption is that losing enough weight makes the disease go away, and that is a fundamental flaw in your proposed protocol. It is a disease that requires perpetual treatment(medical and/or surgical in combination with healthy lifestyle implementation). The assumption you are making is that most people possess extraordinary will power. Enough will power to overcome the main symptom of the disease and change one’s appearance and health projections. For those that are able(very very small %, great for them). Diet and exercise are unquestionable part of any good doctor’s recommendation, but that is no different than any good doctor talking to any patient about being healthy.

Once wider acceptance occurs that obesity is a chronic disease that requires perpetual treatment, the gen pop’s thinking and stigma around it will start to change. We must move away from the fat shaming culture(I am aware this board is full of pots calling the kettle black) and to a place of understanding and acceptance of medical facts and data.

If a person is capable of getting off any medicine that treats any chronic illness with a net positive that is weighed out between new/reduced risks of being off the medicine vs new/reduced risks of being on the medicine. That would be advisable for anyone, regardless of medicine and disease.

The foundational assumption is what I am addressing. The treatment of obesity with a will power based approach is simply lacking in understanding of the disease. I’m sorry.
This post was edited on 3/13/24 at 6:28 am
Posted by Powerman
Member since Jan 2004
162258 posts
Posted on 3/13/24 at 6:43 am to
quote:

If you need to lose 50-80 pounds, diet, training, cardio and carb manipulation will drop most of the weight needed in 3-6 months


Carb manipulation?

Sounds like the most made up shite of all time
Posted by lsu777
Lake Charles
Member since Jan 2004
31419 posts
Posted on 3/13/24 at 8:21 am to
quote:

Obesity is a disease.


99% of cases no it isnt. not from a physical standpoint. unless you have a metabolic disorder its almost 100% from over eating. its a simple thermo calculations. we have dozen and dozens of meta analysis of hundreds of studies proving this

we have seen that when we put people on 8-10k steps and reduce caloric intake, we lose weight. why do people gain it in the first place...99% of the time its life style

quote:

If your body doesn’t naturally produce enough GLP-1, it doesn’t.


this is a rare condition, stop acting like everyone fat has it. gtfo with that shite or cite your study showing lack of glp-1 release after a meal is prevalent


quote:

Your assumption is that losing enough weight makes the disease go away, and that is a fundamental flaw in your proposed protocol. It is a disease that requires perpetual treatment(medical and/or surgical in combination with healthy lifestyle implementation)


no it is not. its lifestyle

can i ask what your back ground is?

quote:

). The assumption you are making is that most people possess extraordinary will power. Enough will power to overcome the main symptom of the disease and change one’s appearance and health projections. For those that are able(very very small %, great for them). Diet and exercise are unquestionable part of any good doctor’s recommendation, but that is no different than any good doctor talking to any patient about being healthy.


in most cases its not an issue of will power, its an issue with lifestyle. you can do 80/20 even 70/30 and if you walk 10k steps per day and lift progressively 2x per week the chance of rebound is small

and for the record i am for the use of the medicine but it should be used a minimum effective doses not the bullshite the doctors are pushing

quote:

Once wider acceptance occurs that obesity is a chronic disease that requires perpetual treatment, the gen pop’s thinking and stigma around it will start to change. We must move away from the fat shaming culture(I am aware this board is full of pots calling the kettle black) and to a place of understanding and acceptance of medical facts and data.


wider acceptance...frick you and frick your acceptance. that is bullshite. its a choice of lifestyles. you keep talking about will power...ITS A frickING CHOCICE!!!


quote:


If a person is capable of getting off any medicine that treats any chronic illness with a net positive that is weighed out between new/reduced risks of being off the medicine vs new/reduced risks of being on the medicine. That would be advisable for anyone, regardless of medicine and disease.


yet the studies show that with lifestyle interventions the rebound effect after getting off is minimal and usually less than 20% of weight lost overall.

quote:

The foundational assumption is what I am addressing.


we will never ever ever ever agree on this unless you can show me studies that glp1 natural release is missing in those that are obese and that even when they keep calories below 2k and NEAT at 10k steps...they still dont lose weight. show me those studies(they dont exist) and you will have my buy in


quote:

The treatment of obesity with a will power based approach is simply lacking in understanding of the disease. I’m sorry.




anything but

again cite your credentials and cite your studies

and FTR i wrote this protocol for the people of this board who do not want to be on the medicine forever and for those using it for aesthetic purposes only like bodybuilders

if i had to do it over again i would actually tell people to not get the name brand, get the bulk and reconstitute yourself, start with half dose and always split dosing across 2 shots per week due to the 5 day half life of glp1's

have you used the protocol? have you tried it on patients or those you are advising? if not...you are talking out your arse and even if you are a doctor i can not respect your opinion at all

either bring the studies to prove me wrong or frick off. I cant stand the whole oh poor me of the fat asses that eat way too much, have no time for exercise yet can tell you about every latest tv show.



back to our regularly scheduled program
Posted by Powerman
Member since Jan 2004
162258 posts
Posted on 3/13/24 at 12:21 pm to
I've heard some people say that if obesity is a disease it's a disease of lack of muscle
Posted by White Raj
Member since Oct 2021
333 posts
Posted on 3/13/24 at 12:39 pm to
quote:

but low carb will help with digestion issues and help get into an even lower caloric deficit.


I'm eating low fat and I'm down 38 lbs in 3 months. I think its much easier to cut calories eating low fat since fat has twice as many calories per gram.

After struggling eating low carb for 7 years, I'm really happy with my low fat diet of lean red meat, beans, rice and oatmeal. I use no oil and very little butter to sear steaks.
Posted by lsu777
Lake Charles
Member since Jan 2004
31419 posts
Posted on 3/13/24 at 12:41 pm to
yea its more of a disease of lack of muscle and lack of NEAT for 95% plus. another 3-4% is a disease of food noise that has been trained into them

i would love to see old boy post studies where people are born not producing glp1. never seen one and i have looked. im not talking morbid obese not producing it anymore, im talking adolescent children who have not reprogrammed their bodies to want to be fat AF.
Posted by White Raj
Member since Oct 2021
333 posts
Posted on 3/13/24 at 12:43 pm to
quote:

Once wider acceptance occurs that obesity is a chronic disease that requires perpetual treatment, the gen pop’s thinking and stigma around it will start to change. We must move away from the fat shaming culture(I am aware this board is full of pots calling the kettle black) and to a place of understanding and acceptance of medical facts and data.


Some say obesity is just a way for the body to store toxic vitamin A.
Posted by BawtHouse
Member since Dec 2021
204 posts
Posted on 3/13/24 at 10:35 pm to
quote:

99% of cases no it isnt.


Making up statistics isn’t helping your cause.

Suffice it to say I am amply qualified to speak on this subject matter.

Are you trying to sell this protocol? That would make A LOT of sense if you are. A lot.

Not going to continue in a back and forth. Everyone should invest a little time in the actual research, instead of taking anyone’s word for it. The science is there and clearly supports what I have presented in this thread. Here are a few to get everyone started.

LINK /

LINK

LINK

LINK /
Posted by lsu777
Lake Charles
Member since Jan 2004
31419 posts
Posted on 3/14/24 at 7:45 am to
quote:

Making up statistics isn’t helping your cause.

Suffice it to say I am amply qualified to speak on this subject matter.


then why are you going against all the literature that is over 50 meta analysis and hundreds of studies that show simply eating less and moving more aka CICO will cause body fat loss?


quote:

Are you trying to sell this protocol? That would make A LOT of sense if you are. A lot.




yea im selling a protocol that i published for free, with items that linked in the op to buy at your local walgreens :rotflmao:



1st link- talks about

quote:

vidence suggests that the action or effect of GLP-1 may be impaired in obese subjects, even in those with normal glucose tolerance. GLP-1 impairment may help explain the increased gastric emptying and decreased satiety signalling seen in obesity


again, i fully acknowledge that glp1 is more than likely impaired with the obese. But what the study does not address is that is...is it impaired because they have become obese or did they become obese because it was impaired from birth?

I am of the belief it is impaired due to lifestyle



2nd study- directly from the study
quote:

Besides dietary nonadherence and physical inactivity, psychiatric, anatomical, genetic, and hormonal causes are suggested to be underlying reasons for WR or IWL post MBS


so the study fully acknowledges that with dietary adherence and physical activity....they would not regain the weight...right?

of course glp1 plays a role in keeping it off...i think you and i can both agree with that and if it is impaired than of course you should get on and stay on a low dose. I am 100% believer in trying to live better through chemistry


3rd link is icing on the cake and proves my point-

quote:

Plasma GLP-1 Response in Obesity
Both early and full relative GLP-1 responses (rAUC0–30 and rAUC0–120) were decreased by 20% in obesity and eight percent in overweight compared with normal weight after adjustment for age, sex and glucose tolerance status (Fig. 2). Comparable results were obtained when using the incremental AUC for GLP-1



so.... glp-1 repsonse is impaired by obesity. the more overweight one is, the more it is impaired. you are not born with the impairment...it is self inflicted in almost all cases.


the last link- its an article first off, dont link opinion articles when i ask for studies. especially when it comes from the assholes at havard who have been proven to be on the take. but the article is just a basic article on glp1s and how they are awesome...no shite, i agree






ok so i think you are misunderstanding some things. Im all for people using glp-1s but there is no need to jump to the highest doses right off the bat and expose yourself to the sides that come from ramping too fast. there are other items such as an EC stack that can be used safely to ramp up metabolism and prolong weight loss at minimum dosing.

2nd the half-life of glp1 is around 5 days, meaning the dose should be split into 2 shots a week minimum if one wants to minimize sides

3rd- lifestyle has to play a part in the process or you arent really taking advantage of the medicine at all. You also open yourself up to massive amounts of muscle loss if protein isnt priortized and progressive resistance training is not introduced. Also if lifestyle changes are not implemented you become a slave to the drug, even with one as amazing as glp1 and all the health benefits...we want to try and avoid this



i am fine with people that need to, staying on the medicine for life. but if you do not have to...dont. its expensive AF for most and if you can teach yourself the lifestyle it takes to live healthy...that is always going to be the preferred path

i would like to know, what part of the protocol do you not agree with? Is it simply that they come off at all? please explain what you dont like about it and maybe you can convince me, if you have the studies to back it up, that im wrong

but how you came at me and the thread to start talking about its a disease and people cant help it etc...well you are on the wrong board for that as many of us were overweight or obese, lost it and have kept it off, including myself.
Posted by Uncle JackD
Member since Nov 2007
58659 posts
Posted on 3/14/24 at 5:04 pm to
Interesting article on GLPs. Nothing surprising to me though. They 100% affect the brain as much as the gut.

LINK

Original article with probable paywall.

This post was edited on 3/14/24 at 5:06 pm
Posted by Long Ball Larry
Baton Rouge
Member since Apr 2021
1398 posts
Posted on 3/14/24 at 5:30 pm to
since your info is often helpful to me , Ill return the favor:

To get rid of paywall / Clean any webpage:
Remove Paywall

simply copy/paste the paywalled site's URL into this site's "clean webpage" box and it works on 95% of sites... the other 5% have recently figured this out and are coming up with ways to avoid it... but for the near future its still useful.. enjoy

Posted by lsu777
Lake Charles
Member since Jan 2004
31419 posts
Posted on 3/14/24 at 6:10 pm to
Thank you for that link
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