Best three day weekend to anywhere in US, three full days

I know there are a lot of well traveled people here. I have two kids 11 and 13. Looking for good “short” trips to take them on. I would ideally leave on a Thursday after work and have all day Friday through Sunday and fly or drive back early Monday. So being a quicker trip will be more hitting the hot spots of wherever. Which I’m fine with. If we like any enough we can go back for longer trips later.

Just looking for general ideas and what you would recommend to do in that timespan wherever it is.

Thanks to all in advance.